ICD-10 Code D82.8 – Immunodeficiency associated with other specified major defects (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D82.8 – Immunodeficiency associated with other specified major defects
What it is
D82.8 identifies an immune deficiency tied to another specified major defect that does not fit a more specific ICD-10 category. Use it when documentation clearly links the immunodeficiency to the named associated defect.
Clinical signs
Clinical features vary; refer to documentation. Commonly, records describe recurrent or unusual infections plus evidence of an underlying major defect affecting immune function.
When to use this code
Use D82.8 when the provider documents immunodeficiency with a specified major defect and no more precise code is available. It is appropriate when the defect is named in the chart and the relationship to immune dysfunction is explicit. Check documentation if the underlying condition is unclear.
Do not use for
Do not use this code for unspecified immunodeficiency or for conditions that have their own specific ICD-10 code. If the record does not identify a major defect, check documentation before assigning D82.8.
Coding tip
Confirm both the immunodeficiency and the associated defect are documented together before you code D82.8.