ICD-10 Code D82.3 – Immunodeficiency following hereditary defective response to Epstein-Barr virus (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D82.3 – Immunodeficiency following hereditary defective response to Epstein-Barr virus
What it is
D82.3 identifies an inherited immunodeficiency linked to an abnormal response to Epstein-Barr virus. Use it when documentation states this specific hereditary defect, not a general immune disorder.
Clinical signs
Clinical features vary; refer to documentation. Standard references describe recurrent or severe EBV-related illness, immune dysfunction, and complications consistent with an underlying hereditary defect.
When to use this code
Use D82.3 when the provider documents immunodeficiency caused by a hereditary defective response to Epstein-Barr virus. It may appear in records describing a confirmed inherited susceptibility with EBV-associated immune problems. If the note only says “immunodeficiency” or “EBV infection,” check documentation.
Do not use for
Do not use this code for routine Epstein-Barr virus infection, nonspecific viral illness, or unspecified immunodeficiency. If the hereditary EBV-related defect is not documented, choose the more accurate code after review.
Coding tip
Code D82.3 only when the hereditary EBV-related immune defect is explicitly documented; otherwise, query the provider.