ICD-10 Code D82 – Immunodeficiency associated with other major defects (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D82 – Immunodeficiency associated with other major defects
What it is
D82 identifies an immunodeficiency that occurs together with other major congenital defects or syndromic abnormalities. Use it when the record documents a broader defect pattern rather than an isolated immune disorder.
Clinical signs
Clinical features vary; refer to documentation. Commonly reported findings include recurrent or unusual infections plus other congenital anomalies affecting different organ systems.
When to use this code
Use D82 when the provider documents immunodeficiency linked to a syndrome or major defect pattern and does not assign a more specific subcategory. It may apply when immune dysfunction is part of a recognized congenital condition. Check documentation for the exact associated defect.
Do not use for
Do not use this code for isolated immune deficiency without major defects, or when a more specific ICD-10-CM code is documented. Check documentation if the condition is better classified elsewhere.
Coding tip
Always code the associated congenital defect or syndrome separately when documented and supported by the record.