ICD-10 Code D68.51 – Activated protein C resistance (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D68.51 – Activated protein C resistance
What it is
Activated protein C resistance is a thrombophilia in which the body does not respond normally to activated protein C, a natural anticoagulant. It is most often associated with an inherited clotting tendency.
Clinical signs
Clinical features vary; refer to documentation. Patients may have a personal or family history of venous thromboembolism, especially recurrent or unprovoked events, and testing may show resistance to activated protein C.
When to use this code
Use D68.51 when the provider documents activated protein C resistance as the diagnosis or a confirmed thrombophilia. It may also be appropriate when the condition is listed as the reason for evaluation or anticoagulation planning. Check documentation if the note only mentions Factor V Leiden without stating resistance.
Do not use for
Do not use this code for general coagulation disorders, unspecified thrombophilia, or a history of thrombosis alone. If the record does not confirm activated protein C resistance, select the documented condition instead.
Coding tip
Code the documented thrombophilia exactly as stated, and verify whether the record supports a confirmed diagnosis or only suspicion.