ICD-10 Code D46 – Myelodysplastic syndromes (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D46 – Myelodysplastic syndromes
What it is
D46 identifies myelodysplastic syndromes, a group of bone marrow disorders where blood cell production is ineffective. Use it when the record documents MDS without a more specific subtype.
Clinical signs
Clinical features vary; refer to documentation. Commonly recorded findings include anemia, fatigue, recurrent infections, easy bruising, or other cytopenias related to marrow dysfunction.
When to use this code
Use D46 when the provider diagnoses myelodysplastic syndrome and does not name a more specific codeable subtype. It also fits follow-up visits for established MDS when the condition remains active and relevant to care. Check documentation if the note only says suspected, ruled out, or history of MDS.
Do not use for
Do not use D46 for leukemia, aplastic anemia, or anemia from another documented cause. If the chart names a specific MDS subtype, code that more specific diagnosis instead.
Coding tip
Code the exact documented MDS subtype whenever the record supports it; otherwise, use D46 and verify whether the encounter is for active disease or history only.