ICD-10 Code D46.C – Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D46.C – Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality
What it is
This code identifies myelodysplastic syndrome with an isolated deletion of the long arm of chromosome 5. Use it when the record specifically documents the del(5q) abnormality as the defining cytogenetic finding.
Clinical signs
Typical findings include anemia and other signs of ineffective blood cell production. Clinical features vary; refer to documentation, especially pathology, cytogenetic, and hematology reports.
When to use this code
Use this code when the clinician documents myelodysplastic syndrome and specifies isolated del(5q) chromosomal abnormality. It is appropriate for confirmed cases supported by bone marrow or cytogenetic results. If the chart mentions MDS without this specific finding, check documentation.
Do not use for
Do not use this code for myelodysplastic syndromes without isolated del(5q), or for other chromosomal abnormalities. Do not assign it when the record is unclear; check documentation.
Coding tip
Look for the word “isolated” with del(5q); without it, this code may not apply.