ICD-10 Code D45 – Polycythemia vera (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D45 – Polycythemia vera
What it is
Polycythemia vera is a chronic myeloproliferative neoplasm that causes overproduction of red blood cells. It may also increase white blood cells and platelets.
Clinical signs
Common findings include plethoric appearance, headache, dizziness, pruritus, and an enlarged spleen. Diagnosis is supported by persistent erythrocytosis and appropriate hematology evaluation; clinical features vary, refer to documentation.
When to use this code
Use D45 when the record clearly documents polycythemia vera, including confirmed or suspected cases being managed as this disorder. Apply it for encounters focused on evaluation, monitoring, or complications of the condition. Do not code it for secondary polycythemia without documentation of PV.
Do not use for
Do not use D45 for relative polycythemia, dehydration-related hemoconcentration, or other causes of increased red cell mass. If the chart only says “polycythemia” without specifying vera, check documentation.
Coding tip
Code D45 only when the provider documents polycythemia vera explicitly or clearly confirms it in the assessment.