ICD-10 Code C81.38 – Lymphocyte depleted Hodgkin lymphoma, lymph nodes of multiple sites (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C81.38 – Lymphocyte depleted Hodgkin lymphoma, lymph nodes of multiple sites
What it is
C81.38 identifies lymphocyte-depleted Hodgkin lymphoma affecting lymph nodes at multiple sites. Use it when the documentation specifies this Hodgkin lymphoma subtype and more than one nodal region is involved.
Clinical signs
Clinical features vary; refer to documentation. Hodgkin lymphoma is commonly identified by enlarged lymph nodes and pathologic confirmation, and the subtype should be stated clearly in the record.
When to use this code
Use this code when the provider documents lymphocyte-depleted Hodgkin lymphoma and notes involvement of lymph nodes in multiple sites. It is appropriate for confirmed diagnoses, including oncology visits and staging-related encounters, when the anatomic distribution is recorded. Check documentation if the site detail is incomplete.
Do not use for
Do not use C81.38 if the chart does not specify the lymphocyte-depleted subtype or if the lymphoma is documented in a single nodal region only. Do not guess the site or histology.
Coding tip
Verify both the histologic subtype and the “multiple sites” location wording before assigning C81.38.