ICD-10 Code C81.37 – Lymphocyte depleted Hodgkin lymphoma, spleen (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C81.37 – Lymphocyte depleted Hodgkin lymphoma, spleen
What it is
This code identifies lymphocyte-depleted Hodgkin lymphoma involving the spleen. It describes a specific, uncommon Hodgkin lymphoma subtype documented as arising in or affecting splenic tissue.
Clinical signs
Clinical features vary; refer to documentation. Findings may include splenic enlargement or other lymphoma-related manifestations, but the diagnosis should be confirmed by pathology or specialist assessment.
When to use this code
Use C81.37 when the provider documents lymphocyte-depleted Hodgkin lymphoma with splenic involvement. Apply it when the spleen is the stated site of disease, whether as the primary documented location or the involved organ in the record. Check documentation if the site is unclear.
Do not use for
Do not use this code for other Hodgkin lymphoma subtypes or for nonspecific lymphoma without a documented lymphocyte-depleted pattern. If the spleen is not explicitly involved, choose the code that matches the documented site.
Coding tip
Match both the histologic subtype and the anatomic site exactly as documented before assigning C81.37.