ICD-10 Code C81.31 – Lymphocyte depleted Hodgkin lymphoma, lymph nodes of head, face, and neck (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C81.31 – Lymphocyte depleted Hodgkin lymphoma, lymph nodes of head, face, and neck
What it is
This code identifies lymphocyte-depleted Hodgkin lymphoma involving lymph nodes in the head, face, or neck. It indicates a specific Hodgkin lymphoma subtype and an anatomic site, so you should confirm both in the record.
Clinical signs
Clinical features vary; refer to documentation. Typical Hodgkin lymphoma findings may include enlarged lymph nodes, often in the neck, and systemic “B” symptoms may be documented, but you should not assume them without clear chart support.
When to use this code
Use C81.31 when the provider documents lymphocyte-depleted Hodgkin lymphoma and specifies lymph node involvement in the head, face, or neck. It is appropriate for confirmed diagnoses, pathology reports, or oncology notes that match this exact site and subtype.
Code it only when the documentation supports both the histology and the location. If the site is stated more generally, or the subtype is not confirmed, check documentation before assigning this code.
Do not use for
Do not use this code for other Hodgkin lymphoma subtypes, unspecified lymphoma, or lymph node disease outside the head, face, and neck. If the record does not clearly identify the subtype, check documentation.
Coding tip
Match the pathology wording exactly; the subtype and anatomic site must both be documented before you assign C81.31.