ICD-10 Code C81.28 – Mixed cellularity Hodgkin lymphoma, lymph nodes of multiple sites (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C81.28 – Mixed cellularity Hodgkin lymphoma, lymph nodes of multiple sites
What it is
C81.28 identifies mixed cellularity Hodgkin lymphoma involving lymph nodes in more than one site. Use it when documentation specifies this Hodgkin lymphoma subtype and multiple nodal regions are affected.
Clinical signs
Clinical features vary; refer to documentation. Common findings in Hodgkin lymphoma may include enlarged lymph nodes, systemic “B” symptoms, or imaging and biopsy results confirming mixed cellularity histology.
When to use this code
Use C81.28 when the provider documents mixed cellularity Hodgkin lymphoma and states that multiple lymph node sites are involved. It is appropriate for confirmed diagnoses on pathology, oncology notes, or discharge summaries. If the record only says Hodgkin lymphoma without subtype or site detail, check documentation.
Do not use for
Do not use this code for other Hodgkin lymphoma subtypes, such as nodular sclerosis or lymphocyte-rich disease. Do not use it when only one lymph node region is documented or when the site is unspecified.
Coding tip
Verify both the histologic subtype and the anatomic extent before assigning C81.28.