ICD-10 Code C81.27 – Mixed cellularity Hodgkin lymphoma, spleen (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C81.27 – Mixed cellularity Hodgkin lymphoma, spleen
What it is
This code identifies mixed cellularity Hodgkin lymphoma involving the spleen. Use it when the record specifically documents this Hodgkin lymphoma subtype and splenic involvement.
Clinical signs
Clinical features vary; refer to documentation. Commonly, Hodgkin lymphoma may present with lymph node enlargement, constitutional symptoms, and splenic involvement noted on exam, imaging, or pathology.
When to use this code
Use C81.27 when the clinician documents mixed cellularity Hodgkin lymphoma of the spleen, or when pathology confirms this subtype with splenic disease. If the record only says Hodgkin lymphoma without subtype or site, check documentation before coding.
This code is appropriate for confirmed splenic involvement, not for suspected lymphoma or nonspecific lymphadenopathy. Code the documented primary site and histology exactly as recorded.
Do not use for
Do not use this code for other Hodgkin lymphoma subtypes, nodular lymphocyte predominant disease, or lymphoma without splenic involvement. Check documentation if the site or histology is unclear.
Coding tip
Verify both the mixed cellularity subtype and spleen involvement in the same record before assigning C81.27.