ICD-10 Code F11.281 – Opioid dependence with opioid-induced sexual dysfunction (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code F11.281 – Opioid dependence with opioid-induced sexual dysfunction
What it is
Use this code for opioid dependence when the patient also has sexual dysfunction caused by opioid use. It identifies both the substance use disorder and the medication-related sexual problem.
Clinical signs
Clinical features vary; refer to documentation. Commonly recorded findings include reduced libido, erectile dysfunction, delayed ejaculation, or other sexual dysfunction attributed to opioids.
When to use this code
Use F11.281 when the provider documents opioid dependence and states the sexual dysfunction is opioid-induced. This may appear in assessment notes, problem lists, or discharge diagnoses. Check documentation if the relationship to opioid use is not clearly stated.
Do not use for
Do not use this code for sexual dysfunction without documented opioid dependence, or when the dysfunction is unrelated to opioids. If the record does not support causation, check documentation.
Coding tip
Assign F11.281 only when both dependence and opioid-induced sexual dysfunction are explicitly documented.