ICD-10 Code E22 – Hyperfunction of Pituitary Gland (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E22 – Hyperfunction of pituitary gland
What it is
E22 identifies hyperfunction of the pituitary gland, meaning the gland is producing too much hormone. Use this code when documentation states pituitary overactivity or a related pituitary hormone excess diagnosis.
Clinical signs
Clinical features vary by the hormone involved; refer to documentation. Common findings may include signs of pituitary hormone excess, such as endocrine changes, growth abnormalities, or symptoms tied to a pituitary adenoma.
When to use this code
Use E22 when the provider documents hyperfunction of the pituitary gland without naming a more specific pituitary disorder. It may also fit when the record describes pituitary hormone overproduction and no more precise ICD-10-CM code is supported. Check documentation for the exact disorder and any associated neoplasm.
Do not use for
Do not use this code for pituitary hypofunction, nonspecific endocrine complaints, or symptoms alone. If the record identifies a specific pituitary tumor or syndrome, code that diagnosis instead.
Coding tip
Confirm the exact pituitary condition and whether a neoplasm or syndrome is documented before assigning E22.