ICD-10 Code D81.82 – Activated Phosphoinositide 3-kinase Delta Syndrome [APDS] (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D81.82 – Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]
What it is
D81.82 identifies activated phosphoinositide 3-kinase delta syndrome, a rare inherited immune disorder. Use it when documentation confirms APDS or a related named diagnosis.
Clinical signs
Clinical features vary; refer to documentation. Commonly reported findings include recurrent infections, enlarged lymph nodes, and immune dysfunction. Some patients also have chronic lung or gastrointestinal involvement.
When to use this code
Use D81.82 when the provider documents APDS, APDS1, APDS2, or activated PI3K delta syndrome as the diagnosed condition. It may appear in specialty notes, genetic evaluations, or immunology problem lists. Code it only when the diagnosis is established, not merely suspected.
Do not use for
Do not use this code for nonspecific recurrent infections, immune deficiency without APDS, or family history alone. Check documentation if the chart only mentions a genetic variant without a confirmed syndrome.
Coding tip
Confirm the exact syndrome name in the record before assigning D81.82.