ICD-10 Code D81.32 – Adenosine deaminase 2 deficiency (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D81.32 – Adenosine deaminase 2 deficiency
What it is
D81.32 identifies adenosine deaminase 2 deficiency, a rare inherited immune disorder. It is used when documentation names this specific condition, often linked to systemic inflammation and immune dysfunction.
Clinical signs
Clinical features vary; refer to documentation. Reported findings may include recurrent fevers, vasculitis, strokes, cytopenias, or other inflammatory manifestations consistent with this diagnosis.
When to use this code
Use D81.32 when the provider documents adenosine deaminase 2 deficiency, ADA2 deficiency, or a confirmed diagnosis of DADA2. Code it for encounters focused on this disorder, including evaluation of related inflammatory or vascular complications. If the record only suggests a possible diagnosis, check documentation before coding.
Do not use for
Do not use this code for adenosine deaminase 1 deficiency or other unspecified immunodeficiency disorders. If the chart does not clearly identify ADA2 deficiency, choose a more accurate documented diagnosis.
Coding tip
Verify the exact gene-related diagnosis in the assessment, because similar names refer to different conditions.