ICD-10 Code D69.51 – Posttransfusion purpura (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D69.51 – Posttransfusion purpura
What it is
Posttransfusion purpura is a rare immune reaction that causes sudden platelet destruction after a blood transfusion. It is coded when documentation identifies this specific transfusion-related thrombocytopenic disorder.
Clinical signs
Typical findings include abrupt purpura, mucosal bleeding, or other bleeding signs after transfusion, often with marked thrombocytopenia. Clinical features vary; refer to documentation.
When to use this code
Use D69.51 when the provider documents posttransfusion purpura, post-transfusion thrombocytopenia, or an immune platelet reaction clearly linked to a recent transfusion. Code it when the record identifies this as the diagnosis, not just unexplained low platelets. Check documentation if the cause is unclear.
Do not use for
Do not use this code for routine thrombocytopenia, bleeding without a transfusion link, or other transfusion reactions that are not posttransfusion purpura. If the chart does not specify this condition, check documentation.
Coding tip
Confirm the transfusion relationship and the exact provider wording before assigning D69.51.