ICD-10 Code D61.81 – Pancytopenia (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D61.81 – Pancytopenia
What it is
Pancytopenia means a reduction in all three major blood cell lines: red blood cells, white blood cells, and platelets. Use this code when the record documents pancytopenia as a diagnosis or confirmed finding.
Clinical signs
Clinical features vary; refer to documentation. Common findings may include fatigue, infection risk, bruising, or bleeding, but you should code based on the documented diagnosis rather than symptoms alone.
When to use this code
Use D61.81 when the clinician clearly documents pancytopenia, including cases described as bone marrow suppression or generalized cytopenia affecting all cell lines. It may be used when the condition is the reason for evaluation, monitoring, or inpatient management.
If pancytopenia is secondary to another condition, code the documented underlying cause as well, when supported by the record. Check documentation if the note only lists abnormal blood counts without naming pancytopenia.
Do not use for
Do not use this code for isolated anemia, leukopenia, or thrombocytopenia without involvement of all three cell lines. If the chart does not confirm pancytopenia, do not assume it from lab abnormalities alone.
Coding tip
Verify that the provider explicitly documents pancytopenia and capture any stated underlying cause separately.