ICD-10 Code C88 – Malignant immunoproliferative diseases and certain other B-cell lymphomas (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C88 – Malignant immunoproliferative diseases and certain other B-cell lymphomas
What it is
C88 identifies a group of rare B-cell lymphomas, including malignant immunoproliferative disorders. These conditions involve abnormal growth of B lymphocytes and related plasma-cell processes.
Clinical signs
Clinical features vary; refer to documentation. Patients may have lymphadenopathy, hepatosplenomegaly, or other findings consistent with an indolent or lymphoplasmacytic B-cell neoplasm.
When to use this code
Use C88 when the record clearly documents a malignant immunoproliferative disease or a qualifying B-cell lymphoma in this category. It is appropriate when the provider names the specific disorder or states the diagnosis within this code family. Check documentation if the chart only says “lymphoma” without subtype.
Do not use for
Do not use C88 for reactive lymphoid hyperplasia, plasma-cell disorders outside this category, or unspecified lymphoma when a more specific code is documented. Check documentation.
Coding tip
Code the most specific documented B-cell lymphoma subtype first, and use C88 only when the record supports this category.