ICD-10 Code C81.22 – Mixed cellularity Hodgkin lymphoma, intrathoracic lymph nodes (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C81.22 – Mixed cellularity Hodgkin lymphoma, intrathoracic lymph nodes
What it is
C81.22 identifies mixed cellularity Hodgkin lymphoma involving the intrathoracic lymph nodes. Use it when documentation specifies this Hodgkin lymphoma subtype and the chest lymph nodes are the site involved.
Clinical signs
Clinical features vary; refer to documentation. Common findings in Hodgkin lymphoma may include enlarged lymph nodes, mediastinal involvement, and systemic “B” symptoms, but the code depends on the recorded diagnosis and site.
When to use this code
Use this code when the provider documents mixed cellularity Hodgkin lymphoma with intrathoracic lymph node involvement, such as mediastinal or other chest nodes. It is appropriate for confirmed diagnoses in inpatient, outpatient, or problem-list documentation. If the subtype or nodal site is not specified, check documentation.
Do not use for
Do not use this code for other Hodgkin lymphoma subtypes, unspecified Hodgkin lymphoma, or lymph node disease outside the thorax. Check documentation if the record only states lymphoma without subtype or anatomic site.
Coding tip
Confirm both the histologic subtype and the intrathoracic nodal site before assigning C81.22.