ICD-10 Code C81.18 – Nodular sclerosis Hodgkin lymphoma, lymph nodes of multiple sites (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C81.18 – Nodular sclerosis Hodgkin lymphoma, lymph nodes of multiple sites
What it is
This code identifies nodular sclerosis Hodgkin lymphoma involving lymph nodes in multiple sites. Use it when documentation specifies this subtype and the disease is not limited to one nodal region.
Clinical signs
Clinical features vary; refer to documentation. Commonly documented findings include enlarged lymph nodes, especially in the neck or chest, and possible “B symptoms” such as fever, night sweats, or unexplained weight loss.
When to use this code
Use C81.18 when the provider documents nodular sclerosis Hodgkin lymphoma and states that multiple lymph node sites are involved. Apply it for confirmed diagnoses in the current encounter, including staging or follow-up notes that still specify active disease. Check documentation if the record is unclear about nodal distribution.
Do not use for
Do not use this code for Hodgkin lymphoma of a single lymph node region or when the subtype is not documented. If the chart says “unspecified Hodgkin lymphoma” or another lymphoma type, choose the more accurate code.
Coding tip
Verify both the histologic subtype and the “multiple sites” wording before assigning C81.18.