ICD-10 Code C75.8 – Malignant neoplasm with pluriglandular involvement, unspecified (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C75.8 – Malignant neoplasm with pluriglandular involvement, unspecified
What it is
This code identifies a malignant neoplasm involving multiple endocrine glands, but the record does not specify which glands are affected. Use it when documentation confirms pluriglandular cancer and no more precise site is stated.
Clinical signs
Clinical features vary; refer to documentation. Findings may reflect mass effect or hormone-related symptoms from one or more involved glands, but the specific presentation depends on the glands and tumor type.
When to use this code
Use C75.8 when the provider documents malignant involvement of more than one gland and does not name a more specific endocrine site. It also fits cases where the chart confirms pluriglandular malignancy, but the exact gland distribution remains unclear. Check documentation if the tumor is described by primary site or metastatic spread.
Do not use for
Do not use this code for a single-gland endocrine malignancy with a known site, or for benign, uncertain, or metastatic disease without documentation of pluriglandular involvement. Check documentation.
Coding tip
Assign the most specific endocrine code available first; use C75.8 only when the record supports multiple glands and no better anatomic code exists.