ICD-10 Code C49.21 – Malignant neoplasm of connective and soft tissue of right lower limb, including hip (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C49.21 – Malignant neoplasm of connective and soft tissue of right lower limb, including hip
What it is
This code identifies a malignant tumor arising in the connective or soft tissues of the right lower limb, including the hip. Use it when documentation specifies the primary site is on the right side.
Clinical signs
Clinical features vary; refer to documentation. Soft tissue sarcomas may present as a growing mass, pain, swelling, or limited movement when the lesion is deep or near joints.
When to use this code
Use C49.21 when the provider documents a malignant neoplasm of connective or soft tissue in the right leg or hip region. It also fits when pathology or imaging confirms the site and laterality. Code the documented primary site, not a nonspecific extremity location.
Do not use for
Do not use this code for benign soft tissue tumors, metastatic disease to the limb, or unspecified laterality. If the record does not clearly state right-sided involvement, check documentation.
Coding tip
Verify both malignancy type and right-sided site in the note before assigning C49.21.