ICD-10 Code C25.8 – Malignant neoplasm of overlapping sites of pancreas (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C25.8 – Malignant neoplasm of overlapping sites of pancreas
What it is
C25.8 identifies a malignant pancreatic tumor that spans two or more adjacent sites within the pancreas. Use it when the documentation says the cancer overlaps pancreatic regions and a single site cannot be assigned.
Clinical signs
Clinical features vary; refer to documentation. Pancreatic cancer may present with abdominal pain, weight loss, jaundice, or imaging showing a mass involving overlapping pancreatic sites.
When to use this code
Use C25.8 when the provider documents a primary pancreatic malignancy involving overlapping anatomic sites, such as head and body, or body and tail. It is appropriate when the record clearly supports overlap and no single pancreatic site is designated. Check documentation if the site is unclear.
Do not use for
Do not use this code for benign pancreatic lesions, metastatic disease to the pancreas, or a tumor limited to one specific pancreatic site. If the documentation only states pancreas cancer without overlap, check documentation.
Coding tip
Code the site exactly as documented; overlapping site codes are not interchangeable with single-site pancreatic codes.