ICD-10 Code C25.4 – Malignant neoplasm of endocrine pancreas (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C25.4 – Malignant neoplasm of endocrine pancreas
What it is
C25.4 identifies a malignant tumor arising in the endocrine portion of the pancreas, also called the pancreatic islets. Use it when the record clearly documents a cancer of the hormone-producing pancreatic tissue.
Clinical signs
Clinical features vary; refer to documentation. Records may note a pancreatic mass, endocrine tumor, or pathology confirming malignancy in the islet cells.
When to use this code
Use C25.4 when the provider documents malignant neoplasm of the endocrine pancreas, including pathology, imaging, or operative reports that localize the cancer to the endocrine pancreas. Code it when the diagnosis is established and the site is clearly specified. Check documentation if the record only says pancreatic cancer without endocrine detail.
Do not use for
Do not use this code for exocrine pancreatic cancers or unspecified pancreatic malignancy. If the site is not clearly the endocrine pancreas, choose the more accurate documented diagnosis.
Coding tip
Verify that the word “endocrine” or an equivalent is documented before assigning C25.4.