ICD-10 Code C22.3 – Angiosarcoma of liver (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C22.3 – Angiosarcoma of liver
What it is
C22.3 identifies angiosarcoma arising in the liver. It is a rare malignant tumor of blood vessel–forming cells and should be coded when the provider documents primary liver angiosarcoma.
Clinical signs
Clinical features vary; refer to documentation. Patients may present with nonspecific liver-related findings such as abdominal pain, hepatomegaly, weight loss, or signs of hepatic dysfunction, but the diagnosis depends on documented pathology or imaging.
When to use this code
Use C22.3 when the record clearly states angiosarcoma of the liver, including confirmed pathology, operative findings, or specialist assessment. Apply it for primary hepatic disease, not for a tumor elsewhere with liver involvement unless the liver is specifically documented as the site.
Do not use for
Do not use this code for benign vascular liver lesions, nonspecific liver masses, or metastatic cancer to the liver without documentation of angiosarcoma. Check documentation if the site or histology is unclear.
Coding tip
Verify that the provider documents both the malignant histology and the liver as the primary site before assigning C22.3.