ICD-10 Code B45.3 – Osseous cryptococcosis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code B45.3 – Osseous cryptococcosis
What it is
Use this code for cryptococcal infection involving bone. It identifies osseous disease caused by Cryptococcus, rather than infection limited to the lungs or central nervous system.
Clinical signs
Clinical features vary; refer to documentation. Typical findings may include localized bone pain, swelling, or imaging evidence of destructive bone lesions with confirmed cryptococcal infection.
When to use this code
Assign B45.3 when the provider documents cryptococcosis of bone, osseous cryptococcosis, or cryptococcal osteomyelitis. Use it when the diagnosis is supported by clinical, imaging, or pathology findings that identify bone involvement.
If the record only states cryptococcosis without a specified site, check documentation before coding. Code the documented site only when bone involvement is clearly identified.
Do not use for
Do not use this code for cryptococcal infection limited to the lungs, meninges, or other non-bone sites. Check documentation if the note does not clearly identify osseous involvement.
Coding tip
Look for the exact anatomic site in the provider note; if bone is not named, do not assume osseous disease.