ICD-10 Code F11.221 – Opioid Dependence with Intoxication Delirium (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code F11.221 – Opioid dependence with intoxication delirium
What it is
F11.221 identifies opioid dependence when the patient is also experiencing delirium caused by opioid intoxication. Use it when documentation links the delirium to opioid use in a dependent patient.
Clinical signs
Delirium typically involves an acute change in attention, awareness, and thinking, with confusion or disorganized behavior. Clinical features vary; refer to documentation for the specific opioid-related findings supporting intoxication delirium.
When to use this code
Use this code when the record clearly states opioid dependence and intoxication delirium in the same encounter. It fits cases where the delirium is attributed to opioid intoxication, not withdrawal or another cause. Check documentation if the relationship is unclear.
Do not use for
Do not use F11.221 if the delirium is due to opioid withdrawal, another substance, or a non-substance medical condition. If dependence or intoxication is not documented, check documentation before assigning this code.
Coding tip
Confirm both the dependence and the intoxication delirium are documented together before coding F11.221.