ICD-10 Code E88.82 – Obesity due to disruption of MC4R pathway (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E88.82 – Obesity due to disruption of MC4R pathway
What it is
E88.82 identifies obesity caused by disruption of the melanocortin-4 receptor (MC4R) pathway. Use it when the record specifically links obesity to this genetic or biologic pathway abnormality.
Clinical signs
Typical findings include early-onset, severe, or persistent obesity, often with a family history or documented MC4R-pathway defect. Clinical features vary; refer to documentation.
When to use this code
Use E88.82 when the provider documents obesity due to MC4R pathway disruption, including genetic confirmation or a clear clinical diagnosis. It may also apply when the chart states obesity from an MC4R-related disorder. If the cause is not documented, check documentation before assigning this code.
Do not use for
Do not use this code for uncomplicated obesity, overweight, or obesity from unspecified causes. If the record does not link the condition to MC4R pathway disruption, use a more general obesity code.
Coding tip
Code E88.82 only when the causal relationship is explicit in the note or test results.