ICD-10 Code E88 – Other and unspecified metabolic disorders (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E88 – Other and unspecified metabolic disorders
What it is
E88 is a broad ICD-10-CM category for metabolic disorders that do not fit a more specific code. Use it when the record documents an other or unspecified metabolic condition and no narrower diagnosis is available.
Clinical signs
Clinical features vary; refer to documentation. Metabolic disorders may present with abnormal weight changes, fatigue, electrolyte or biochemical abnormalities, or findings tied to a specific inherited or acquired metabolic problem.
When to use this code
Use E88 when the provider clearly documents an “other” metabolic disorder or an unspecified metabolic disorder and the chart does not support a more specific code. It may apply when the condition is named but not indexed elsewhere, or when documentation is insufficient for a finer diagnosis. Check documentation for the exact disorder and any associated manifestations.
Do not use for
Do not use E88 for a specific metabolic disease that has its own ICD-10-CM code. Avoid it when the record only shows abnormal laboratory findings without a diagnosed metabolic disorder.
Coding tip
Code the most specific metabolic diagnosis documented, and query for clarification if the provider’s wording is vague.