ICD-10 Code E74.21 – Galactosemia (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E74.21 – Galactosemia
What it is
Galactosemia is an inherited disorder of carbohydrate metabolism in which the body cannot properly process galactose, a sugar found in milk and dairy products. This code identifies the diagnosed condition, not a family history or carrier state.
Clinical signs
Clinical features vary; refer to documentation. Typical findings may include poor feeding, vomiting, jaundice, lethargy, and failure to thrive in affected infants. Diagnosis is usually confirmed by metabolic testing and genetic evaluation.
When to use this code
Use E74.21 when the provider documents galactosemia as the active diagnosis, including classic or other specified forms if not further classified elsewhere. It is appropriate for confirmed congenital disease, newborn screening follow-up, or ongoing management of the disorder. Do not use it for simple lactose intolerance.
Do not use for
Do not use this code for lactose intolerance, nonspecific milk intolerance, or suspected galactosemia without confirmation. Check documentation if the record only notes abnormal screening results or a family history.
Coding tip
Code E74.21 only when the chart clearly supports galactosemia; otherwise, document the screening result or family history separately.