ICD-10 Code E74.12 – Hereditary fructose intolerance (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E74.12 – Hereditary fructose intolerance
What it is
E74.12 identifies hereditary fructose intolerance, an inherited disorder of fructose metabolism. It is used when the diagnosis is documented and the condition affects dietary handling of fructose, sucrose, or sorbitol.
Clinical signs
Clinical features vary; refer to documentation. Commonly documented findings include vomiting, abdominal pain, poor feeding, hypoglycemia, and liver involvement after fructose exposure.
When to use this code
Use this code when the provider documents hereditary fructose intolerance as the confirmed diagnosis. It also applies when the record clearly states the disorder is congenital or inherited and is being managed as a chronic metabolic condition.
Code it from problem lists, discharge summaries, or specialist notes when the diagnosis is active. Check documentation if the chart only mentions fructose avoidance without naming the disorder.
Do not use for
Do not use E74.12 for simple food intolerance, nonspecific abdominal symptoms, or suspected fructose sensitivity without a documented diagnosis. Check documentation if the condition is only being ruled out.
Coding tip
Assign E74.12 only when hereditary fructose intolerance is explicitly stated; diet restriction alone is not enough.