ICD-10 Code E72.5 – Disorders of glycine metabolism (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E72.5 – Disorders of glycine metabolism
What it is
E72.5 identifies inherited or acquired disorders that affect glycine handling in the body. These conditions can disrupt normal amino acid metabolism and lead to abnormal glycine buildup or related biochemical changes.
Clinical signs
Clinical features vary; refer to documentation. Common findings may include neurologic problems, developmental delay, seizures, or metabolic abnormalities consistent with a glycine disorder.
When to use this code
Use E72.5 when the provider documents a disorder of glycine metabolism, including a confirmed metabolic diagnosis. It may also apply when the record clearly identifies a glycine-related amino acid disorder without a more specific code.
Do not guess based on nonspecific neurologic symptoms or abnormal screening results alone. Code the documented diagnosis and any confirmed subtype if available.
Do not use for
Do not use this code for general amino acid disorders, nonspecific hyperglycinemia, or symptoms without a documented metabolic diagnosis. Check documentation.
Coding tip
Query for the exact metabolic subtype when the chart mentions glycine abnormalities but does not name a specific disorder.