ICD-10 Code E71.521 – Adolescent X-linked adrenoleukodystrophy (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E71.521 – Adolescent X-linked adrenoleukodystrophy
What it is
E71.521 identifies adolescent X-linked adrenoleukodystrophy, a genetic disorder that affects the nervous system and adrenal function. Use it when the record documents this specific adolescent form.
Clinical signs
Clinical features vary; refer to documentation. Commonly documented findings include progressive neurologic decline, behavioral or school changes, gait problems, and evidence of adrenal involvement in a male patient with X-linked disease.
When to use this code
Use this code when the clinician documents adolescent X-linked adrenoleukodystrophy as the confirmed diagnosis. It may appear in neurology, genetics, or metabolic disorder records, including follow-up visits after prior confirmation. If the note only says “adrenoleukodystrophy,” check documentation for the age-specific subtype.
Do not use for
Do not use this code for other leukodystrophies, nonspecific peroxisomal disorders, or adrenal insufficiency without documented X-linked adrenoleukodystrophy. Check documentation if the age group or subtype is unclear.
Coding tip
Code the documented subtype exactly; age and X-linked form matter here.