ICD-10 Code A52.1 – Symptomatic Neurosyphilis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code A52.1 – Symptomatic neurosyphilis
What it is
A52.1 identifies symptomatic neurosyphilis, a syphilis infection that has affected the central nervous system and is causing clinical symptoms. Use it when documentation clearly states symptomatic involvement of the brain, spinal cord, or nerves.
Clinical signs
Clinical features vary; refer to documentation. Reported findings may include cognitive changes, sensory or motor deficits, cranial nerve abnormalities, gait problems, or other neurologic symptoms linked to syphilis.
When to use this code
Use this code when the provider documents symptomatic neurosyphilis, neurosyphilis with neurologic manifestations, or a confirmed CNS complication of syphilis. It applies when the condition is active and symptoms are part of the diagnosis. Check documentation if the record only mentions syphilis exposure or screening.
Do not use for
Do not use A52.1 for asymptomatic neurosyphilis, latent syphilis, or nonspecific neurologic symptoms without a documented syphilis-related cause. Check documentation if the chart does not clearly link the neurologic findings to syphilis.
Coding tip
Code A52.1 only when the provider explicitly connects neurologic disease to syphilis; otherwise, query or code the documented condition separately.