ICD-10 Code E31.0 – Autoimmune Polyglandular Failure (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code E31.0 – Autoimmune polyglandular failure
What it is
E31.0 identifies autoimmune polyglandular failure, a condition in which the immune system attacks two or more endocrine glands. It is used when documentation shows a recognized autoimmune polyglandular syndrome.
Clinical signs
Clinical features vary; refer to documentation. Commonly reported findings include combinations of endocrine gland failure such as adrenal, thyroid, or parathyroid involvement, along with other autoimmune disease manifestations.
When to use this code
Use this code when the record specifically documents autoimmune polyglandular failure or a related autoimmune polyglandular syndrome. It may also fit when multiple endocrine insufficiencies are clearly linked to an autoimmune process. Check documentation for the exact syndrome type and associated gland involvement.
Do not use for
Do not use this code for isolated endocrine disorders without autoimmune polyglandular disease. If the chart only mentions one gland disorder or an unspecified autoimmune condition, check documentation before assigning E31.0.
Coding tip
Code the autoimmune syndrome only when the provider explicitly links multiple gland failures to autoimmunity.