ICD-10 Code D80.8 – Other immunodeficiencies with predominantly antibody defects (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D80.8 – Other immunodeficiencies with predominantly antibody defects
What it is
D80.8 identifies an immunodeficiency disorder in which antibody-related immune function is impaired, but the condition does not fit a more specific ICD-10 category. Use it when the record clearly supports a predominantly antibody defect and no other D80 code applies.
Clinical signs
Patients may have recurrent or unusual infections, especially involving the sinuses, ears, lungs, or gastrointestinal tract. Clinical features vary; refer to documentation for the specific immune defect, associated laboratory findings, or specialist diagnosis.
When to use this code
Use D80.8 when the provider documents an antibody deficiency or related immunodeficiency and names it as “other” or otherwise unspecified within the predominantly antibody defect group. It is appropriate when the chart supports immune dysfunction but not a more exact subtype. Check documentation if the diagnosis is only suspected.
Do not use for
Do not use this code for combined immunodeficiencies, secondary immunodeficiency, or a specific antibody disorder with its own ICD-10 code. If the record names a more specific diagnosis, code that condition instead.
Coding tip
Match the code to the provider’s exact immunodeficiency wording and avoid defaulting to D80.8 when a more specific antibody defect is documented.