ICD-10 Code D80.6 – Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D80.6 – Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
What it is
D80.6 identifies an antibody deficiency disorder where immunoglobulin levels may appear near normal or elevated, yet the immune response is still inadequate. Use it for documented humoral immune deficiency with this specific pattern.
Clinical signs
Patients may have recurrent or persistent infections, especially sinopulmonary infections, despite immunoglobulin results that do not show classic low levels. Clinical features vary; refer to documentation.
When to use this code
Use D80.6 when the record clearly states antibody deficiency with near-normal immunoglobulins or hyperimmunoglobulinemia. It may also fit specialist notes describing impaired antibody function with recurrent infections and supporting immunology workup. Check documentation if the diagnosis is broader or unspecified.
Do not use for
Do not use this code for general hypogammaglobulinemia, selective immunoglobulin deficiencies, or unspecified immune disorders. If the chart does not confirm this exact antibody deficiency pattern, choose a more accurate code.
Coding tip
Code D80.6 only when the provider documents the specific antibody deficiency pattern, not just abnormal immunoglobulin testing.