ICD-10 Code D61.01 – Constitutional (pure) red blood cell aplasia (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D61.01 – Constitutional (pure) red blood cell aplasia
What it is
This code identifies a congenital or inherited failure of red blood cell production affecting the marrow. It is used for constitutional pure red cell aplasia, where anemia results from reduced erythroid precursors.
Clinical signs
Patients typically show anemia-related findings such as pallor, fatigue, and weakness. Clinical features vary; refer to documentation for the specific hereditary presentation and whether other blood cell lines are preserved.
When to use this code
Use D61.01 when the record clearly documents constitutional or congenital pure red blood cell aplasia, not an acquired aplastic process. It is appropriate when the provider specifies isolated red cell aplasia as the diagnosis. Check documentation if the chart only says anemia without confirming the disorder.
Do not use for
Do not use this code for acquired aplastic anemia, iron deficiency anemia, or other nonspecific anemias. If the cause is unclear or another marrow disorder is documented, choose the more specific confirmed diagnosis.
Coding tip
Assign D61.01 only when the provider documents constitutional pure red cell aplasia or an equivalent congenital term.