ICD-10 Code D58.0 – Hereditary spherocytosis (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D58.0 – Hereditary spherocytosis
What it is
Hereditary spherocytosis is an inherited hemolytic anemia caused by abnormal red blood cell membranes. The cells become sphere-shaped and break down more easily than normal.
Clinical signs
Common findings include anemia, jaundice, splenomegaly, and a family history of similar disease. Clinical features vary; refer to documentation.
When to use this code
Use D58.0 when the record specifically documents hereditary spherocytosis as the diagnosis. Apply it for confirmed inherited spherocytic hemolytic anemia, whether newly diagnosed or longstanding. If the chart only notes hemolytic anemia without the hereditary spherocytosis diagnosis, check documentation.
Do not use for
Do not use this code for acquired hemolytic anemia, nonspecific anemia, or other hereditary hemolytic disorders. Do not assign it when the provider has not documented hereditary spherocytosis.
Coding tip
Code D58.0 only when the provider names the condition; otherwise query for clarification.