ICD-10 Code D55.29 – Anemia due to other disorders of glycolytic enzymes (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code D55.29 – Anemia due to other disorders of glycolytic enzymes
What it is
D55.29 identifies anemia caused by inherited or acquired defects in glycolytic enzymes other than the specifically listed ones. The red blood cells break down too early because energy production is impaired.
Clinical signs
Typical findings include chronic anemia, pallor, fatigue, and sometimes jaundice or splenomegaly. Clinical features vary; refer to documentation for the exact enzyme disorder and supporting evidence.
When to use this code
Use this code when the provider documents anemia due to a glycolytic enzyme defect that is not named elsewhere in ICD-10-CM. It is appropriate when the record links the anemia to that enzyme abnormality. If the note only says “hemolytic anemia” without a cause, check documentation.
Do not use for
Do not use D55.29 for anemia from iron deficiency, blood loss, or other non-enzymatic causes. Also avoid it when the specific glycolytic enzyme disorder is documented under a different code.
Coding tip
Code the documented cause first and verify that the enzyme defect is not captured by a more specific ICD-10-CM option.