ICD-10 Code C94.21 – Acute megakaryoblastic leukemia, in remission (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C94.21 – Acute megakaryoblastic leukemia, in remission
What it is
This code identifies acute megakaryoblastic leukemia that is no longer active and is documented as in remission. Use it when the record clearly states the leukemia has responded and is not currently being treated as active disease.
Clinical signs
Clinical features vary; refer to documentation. Acute megakaryoblastic leukemia is a subtype of acute myeloid leukemia involving megakaryoblasts, and remission means signs of active leukemia have improved or resolved.
When to use this code
Use this code when the provider documents acute megakaryoblastic leukemia as “in remission,” “in complete remission,” or similar wording. It is appropriate for follow-up encounters after successful treatment when the leukemia remains a historical active condition but is not currently active.
Check documentation if the chart only mentions a past history of leukemia without stating remission status. If the note describes relapse, persistent disease, or active treatment for leukemia, this code is not appropriate.
Do not use for
Do not use this code for active acute megakaryoblastic leukemia or for unspecified leukemia history. If remission is not documented, or if the condition is relapsed or refractory, check documentation for the correct code.
Coding tip
Code only when the provider explicitly documents remission; do not infer remission from treatment history alone.