ICD-10 Code C92.1 – Chronic myeloid leukemia, BCR/ABL-positive (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C92.1 – Chronic myeloid leukemia, BCR/ABL-positive
What it is
C92.1 identifies chronic myeloid leukemia with the BCR/ABL fusion gene. Use it for this specific myeloproliferative neoplasm when the record confirms BCR/ABL-positive disease.
Clinical signs
Typical findings include leukocytosis, splenomegaly, fatigue, and sometimes weight loss or early satiety. Clinical features vary; refer to documentation for confirmation of chronic phase and BCR/ABL positivity.
When to use this code
Use C92.1 when the provider documents chronic myeloid leukemia, chronic granulocytic leukemia, or CML with BCR/ABL positivity. It also fits follow-up visits when the diagnosis remains active and documented.
Apply it only when the condition is clearly identified as CML, not another leukemia or unspecified myeloproliferative disorder. If the chart does not confirm BCR/ABL status, check documentation before coding.
Do not use for
Do not use C92.1 for acute leukemias, other myeloid neoplasms, or CML without documented BCR/ABL positivity. Check documentation if the diagnosis is only suspected.
Coding tip
Code the exact leukemia type and molecular status from the provider’s wording, and verify whether the note supports C92.1 or a different leukemia code.