ICD-10 Code C49.0 – Malignant neoplasm of connective and soft tissue of head, face and neck (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C49.0 – Malignant neoplasm of connective and soft tissue of head, face and neck
What it is
This code identifies a malignant tumor arising from connective or soft tissue in the head, face, or neck. Use it when the documentation specifies this anatomic site and a soft tissue primary malignancy.
Clinical signs
Clinical features vary; refer to documentation. Common findings may include a growing mass, pain, swelling, or local tissue invasion, but the record should support the diagnosis and site.
When to use this code
Use C49.0 when the provider documents a primary malignant neoplasm of soft tissue or connective tissue located in the head, face, or neck. It also fits when pathology or imaging confirms the site and malignancy, and no more specific code is documented. If the record only says “soft tissue sarcoma” without location, check documentation.
Do not use for
Do not use this code for benign soft tissue tumors, skin cancers, or malignancies clearly arising from bone, salivary gland, or lymphoid tissue. Check documentation if the site is uncertain or if the lesion is metastatic rather than primary.
Coding tip
Confirm both the malignant nature and the exact head, face, or neck soft tissue site before assigning C49.0.