ICD-10 Code C25.3 – Malignant neoplasm of pancreatic duct (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C25.3 – Malignant neoplasm of pancreatic duct
What it is
C25.3 identifies a malignant tumor arising in the pancreatic duct. Use it when documentation specifies ductal involvement rather than the pancreas in general.
Clinical signs
Clinical features vary; refer to documentation. Commonly, records describe a pancreatic duct malignancy confirmed by imaging, biopsy, or operative findings.
When to use this code
Use this code when the provider documents primary cancer of the pancreatic duct. It also fits when pathology or imaging clearly localizes the malignancy to the duct. If the note only says “pancreatic cancer” without duct detail, check documentation before assigning C25.3.
Do not use for
Do not use it for benign pancreatic duct disease, pancreatitis, or unspecified pancreatic malignancy. If the cancer site is the pancreas broadly or another pancreatic structure, choose the documented site instead.
Coding tip
Code the most specific pancreatic site stated in the record; if the duct is not named, verify before defaulting to C25.3.