ICD-10 Code C22.8 – Malignant neoplasm of liver, primary, unspecified as to type (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C22.8 – Malignant neoplasm of liver, primary, unspecified as to type
What it is
C22.8 identifies a primary malignant tumor in the liver when the specific histology or type is not documented. Use it when the record confirms liver cancer but does not name a more specific primary liver malignancy.
Clinical signs
Clinical features vary; refer to documentation. Common findings may include imaging evidence of a liver mass, abnormal liver evaluation, or biopsy confirming malignancy without a more specific tumor type.
When to use this code
Use this code when the provider documents a primary liver cancer and does not specify hepatocellular carcinoma, intrahepatic bile duct cancer, or another defined type. It also fits when pathology or imaging confirms malignancy but the exact primary type remains unspecified. Check documentation for primary site and tumor details.
Do not use for
Do not use C22.8 for metastatic disease to the liver or for secondary liver tumors. If the record names a specific liver cancer type, code that more precise diagnosis instead.
Coding tip
Confirm the tumor is primary to the liver and not secondary before assigning C22.8.