ICD-10 Code C22.1 – Intrahepatic bile duct carcinoma (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code C22.1 – Intrahepatic bile duct carcinoma
What it is
C22.1 identifies a malignant tumor arising from the bile ducts within the liver. Use it for documented intrahepatic cholangiocarcinoma or similar wording that clearly indicates an intrahepatic bile duct primary.
Clinical signs
Clinical features vary; refer to documentation. Commonly recorded findings include jaundice, right upper abdominal pain, unexplained weight loss, or imaging showing a mass in the intrahepatic bile ducts.
When to use this code
Use C22.1 when the provider documents primary cancer of the intrahepatic bile ducts or intrahepatic cholangiocarcinoma. Apply it for confirmed malignancy, whether newly diagnosed or under active evaluation, when the site is clearly intrahepatic. Check documentation if the record only says “bile duct cancer.”
Do not use for
Do not use this code for extrahepatic bile duct carcinoma, gallbladder cancer, or nonspecific liver tumors. If the documentation does not specify the intrahepatic site, check documentation before coding.
Coding tip
Confirm that the word “intrahepatic” appears in the diagnosis or pathology report before assigning C22.1.