ICD-10 Code I25.112 – Atherosclerotic heart disease of native coronary artery with refractory angina pectoris (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code I25.112 – Atherosclerotic heart disease of native coronary artery with refractory angina pectoris
What it is
This code identifies coronary artery disease in a native coronary artery with angina that persists despite usual therapy. It reflects documented atherosclerotic heart disease and ongoing refractory chest pain symptoms.
Clinical signs
Clinical features vary; refer to documentation. Commonly, the record shows known coronary atherosclerosis plus angina that remains difficult to control, often with repeated chest discomfort or persistent ischemic symptoms.
When to use this code
Use I25.112 when the provider documents native coronary artery disease and specifically states refractory angina pectoris. Apply it when the angina is not adequately relieved by standard management and the diagnosis is clearly linked to atherosclerotic heart disease.
Choose this code only if the record supports both the coronary atherosclerosis and the refractory angina qualifier. Check documentation if the chart says stable angina, unspecified chest pain, or angina without the refractory designation.
Do not use for
Do not use this code for angina without documented atherosclerotic heart disease or for chest pain of unclear cause. Do not assign it when the angina is not described as refractory.
Coding tip
Confirm that the provider links the refractory angina to native coronary atherosclerosis before coding I25.112.