ICD-10 Code M05.6 – Rheumatoid arthritis with involvement of other organs and systems (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code M05.6 – Rheumatoid arthritis with involvement of other organs and systems
What it is
This code identifies seropositive rheumatoid arthritis when the disease also affects organs or systems beyond the joints. Use it when documentation shows rheumatoid arthritis with extra-articular involvement, not isolated joint disease.
Clinical signs
Findings may include inflammatory arthritis with documented involvement of organs or systems such as skin, lungs, eyes, or blood vessels. Clinical features vary; refer to documentation for the specific extra-articular manifestation.
When to use this code
Use M05.6 when the provider documents rheumatoid arthritis plus involvement of other organs or systems, and the record does not specify a more exact subcategory. Code the additional manifestation separately when documented and supported by ICD-10-CM guidance.
Choose this code for confirmed rheumatoid arthritis cases with extra-articular disease. If the chart only notes joint symptoms or suspected rheumatoid arthritis, check documentation before assigning M05.6.
Do not use for
Do not use this code for rheumatoid arthritis without extra-articular involvement or for non-rheumatoid inflammatory arthritis. Check documentation if the record describes only joint disease or an unspecified systemic condition.
Coding tip
Verify that the provider links the organ or system involvement to rheumatoid arthritis before coding M05.6.