ICD-10 Code G90.B – LMNB1-related autosomal dominant leukodystrophy (2026): Diagnosis, Symptoms & Billing Guide
2026 ICD-10-CM Diagnosis Code G90.B – LMNB1-related autosomal dominant leukodystrophy
What it is
G90.B identifies LMNB1-related autosomal dominant leukodystrophy, a rare inherited white-matter disorder caused by LMNB1 gene duplication. It reflects a progressive demyelinating disease affecting the central nervous system.
Clinical signs
Clinical features vary; refer to documentation. Typical findings include progressive gait difficulty, spasticity, urinary dysfunction, and cognitive or cerebellar changes consistent with leukodystrophy.
When to use this code
Use this code when the record specifically documents LMNB1-related autosomal dominant leukodystrophy or confirmed LMNB1 duplication with the corresponding diagnosis. You may also use it when the clinician clearly links progressive demyelinating disease to this genetic cause.
Do not infer the condition from nonspecific neurologic symptoms alone. Check documentation if the note mentions leukodystrophy without a named genetic etiology.
Do not use for
Do not use for unspecified leukodystrophy, other inherited white-matter disorders, or symptoms such as weakness or gait disturbance without a confirmed diagnosis.
Coding tip
Confirm that the provider documents the LMNB1-related diagnosis or genetic confirmation before assigning G90.B.